Korea Institute of Science and Technology

Chang Bae Jin

Hyoung Ja Kim

Jae Yeol Lee

Yong Sup Lee

Hyun Beom Lee

You Bin Cho

Hyun Soo Choi

Chang Soo Yook

Min Jeoung Son

Disclosed are aalcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from aethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, thealcoholic extract and the solvent fractions or the novel compounds 1 and 2.

Food compositions and pharmaceutical compositions containingextract for lowering blood cholesterol levels and for ameliorating atherosclerosis

The present invention relates to anextract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. Theextract, the fraction thereof and 6'-O-caffeoylampelopsisionoside, 6&#x2032;-O-caffeoylroseoside, 6&#x2032;-O-caffeoylsonchuinoside C, 6&#x2032;-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, theextract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

[object Object]

Growing community of inventors

Seoul, South Korea

Chang Bae Jin