University of California

Los Alamos National Security, LLC

Chanel Kitmon Yee

Basil I Swanson

Jose-Maria Sansinena

Antonio Redondo

Atul Navinchandra Parikh

Annapoorna R Sapuri/Butti

Meri Lynn Amweg

Atul N Parikh

Calvin Yang

The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.

Membrane architectures for ion-channel switch-based electrochemical biosensors

This invention provides novel methods for creation of patterned lipid bilayer membranes as well as methods for refunctionalization of such patterned membranes with selected components. Such components optionally comprise, e.g., lipid bilayer membranes (which optionally comprise specific proteins), proteins, non-biologic moieties, etc.

Direct micro-patterning of lipid bilayers using UV light and selected uses thereof

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Davis, CA, United States of America

Chanel Kitmon Yee