University of Texas System

C. R. Bard, Inc.

Pathak Holdings LLC

Incept, LLC

Focal, Inc.

Covidien LP

Sulzer Carbomedics Inc.

Ev3 Peripheral, Inc.

Genzyme Corporation

Carbomedics Inc.

Novocell, Inc.

Angiomed Gmbh & Co. Medizintechnik Kg

Chandrashekhar Prabhakar Pathak

Amarpreet S Sawhney

Jeffrey Alan Hubbell

Neil P Desai

Arthur J Coury

Jennifer L Hill

Luis Z Avila

Shikha P Barman

Syed F Hossainy

Dnyanesh A Talpade

R Michael Casanova

Syed F A Hossainy

Peter G Edelman

C Michael Philbrook

Jennifer L Hill-West

Mark T Kieras

Sanjay M Thigle

Stephen Jack Herman

Patrick K Campbell

Peter K Jarrett

Laurence A Roth

Mark A Moore

Kevin M Berrigan

Tarun J Edwin

Richard K Elton

David L Bogert

Jamie Abbott

Heidi R Cole

Fitzroy Brown

Kereshmeh Shahriari

James Howard Dreher

Richard E Phillips, Jr

Richard E Philips, Jr

John Paul Ranieri

Joseph Andrew Chinn

Rama Akella

Joseph A Sauter

Thiemo Blank

Robert G Lerdahl

Chris Steadham

Jeffrey A Hubbell

L Diane Bruce

Michael Casanova

Robert Michael Casanova

John D Mcdermott

John Ranieri

This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.

Methods, compositions, and devices for making sustained biodegradable implants in tissue

A method of forming an implant in tissue can include: providing a polymer solution having an effective amount of polymer dissolved in a biocompatible, water-soluble organic solvent; injecting a plurality of droplets of the polymer solution in the tissue; fusing the injected droplets together; dissipating the biocompatible, water-soluble organic solvent in the tissue; and precipitating the polymer from the injected polymer solution so as to form the implant.

Compositions, methods and devices for forming implants from injected liquids

A method of making an intracorporeal marker, including the method steps of providing a core having a first material with porous hydroxyapatite; and completely covering the core an outer region having a second material with less porous hydroxyapatite, wherein ultrasonic or radiative imaging reveals a difference between the marker and tissue.

Multiple imaging mode tissue marker

Method of making an in situ sustained biodegradable drug delivery implant by filling an artificial tissue cavity

A method of forming an implant in a tissue can include: providing an injectable liquid composition comprising one or more precursors of a crosslinkable composition; injecting the injectable composition into the tissue at the rate of about 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per injection; and crosslinking the one or more precursors of the crosslinkable composition so as to form a crosslinked composition.

Methods for forming implants from injected thermoreversible gels

A marker includes a core and an outer region. The core has a first material with porous hydroxyapatite. The outer region completely covers the core, and has a second material with less porous hydroxyapatite, wherein ultrasonic or radiative imaging reveals a difference between the marker and tissue.

Methods and compositions are for preparing microimplant arrays for sustained drug delivery or live cell based therapy. The 'array in array' (AIA) device enables formation of microimplant arrays without having tissue piercing elements to the microimplant. The methods and compositions are for solid state delivery of drugs, especially biologics drugs without forming a drug solution prior to injection. New methods and compositions are for preparing in situ arrays for sustained drug delivery or live cell based therapy. Tissue surface is first treated with laser drilling, microneedle array, mechanical drilling or other methods to create artificial micro-porosity of various sizes, shapes and patterns. The artificial pores created are then infused with sustained drug delivery compositions or live cell suspensions. The compositions are converted into solid or semisolid state by physical or chemical reaction/s to entrap drug or live cells. The entrapped drug or live cells provide local or systemic therapeutic benefit.

Methods, compositions, and devices for drug/live cell microarrays

A self-sealing vascular graft, including a substrate with a sealant layer and several optional additional layers, is described. The substrate can be ePTFE and the material used for the sealant and additional layers can be polyurethane. The sealant layer and additional layers may include one or more base layers, one or more foam layers, beading of different sizes and shapes, and ePTFE tape. A flared cuff may be integral to one or both ends of the substrate or may be attached to one or both ends. Various methods of making a self-sealing vascular graft are also described, including methods of disposition, methods of forming, methods of bonding and methods of attaching.

Self-sealing PTFE graft with kink resistance

A method of forming a gel implant in tissue can include: providing an injectable composition configured for thermoreversible gel formation at about 37&#xb0; C.; injecting the injectable composition into the tissue at the rate of about 10-12000 injections per minute; and forming a thermoreversible gel at about 37&#xb0; C. from the injected injectable composition so as to form the gel implant. The injecting can be at an amount of 1.0E-02 ml to 1.0E-16 ml per needle per injection. The injecting can form an implant with area greater than or equal to 5 mm. The injecting can be at a depth of 10 microns to 5 mm. The injectable composition can include a visualization agent, drug or other agent.

Compositions, methods and devices for forming gel implants from injected liquids

A method of forming an implant in the tissue can include: providing an injectable composition having a neat liquid carrier, wherein the neat liquid carrier is substantially liquid at room temperature and/or about body temperature; and injecting the neat liquid solution into the tissue at the rate of 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per needle per injection. The neat liquid carrier can be polymeric or non-polymeric. The neat liquid carrier can be biodegradable. The neat liquid carrier can include a viscosity-modifying agent. The injecting can form an implant with area greater than or equal to 5 mm. The neat liquid carrier can be injected at a depth of 10 microns to 5 mm. The neat liquid solution can include a drug or other agent.

A stent graft is disclosed and can include a stent and a graft engaged with the stent. The graft can include an inner surface and an outer surface. Further, at least one of the inner surface and the outer surface can include a plurality of protrusions as viewed in cross section extending through a longitudinal axis.

Kink resistant stent graft

An intracorporeal tissue marker includes a first material comprising a core region of the marker. The first material has a first density. A second material completely surrounds the first material. The second material is distinct from the first material and has a second density. The first density of the first material is lower than the second density of the second material.

A wall, for example the wall of a vascular graft, has multiple channels within it. The channels may be used to hold drugs or reinforcing fibers. The channels may have a predetermined roughness. The channels may be formed by coextrusion using a soluble material, for example, to define the channels and then dissolving them to open the channels in the extrudate.

Vascular grafts with multiple channels and methods for making

This invention provide novel compositions, methods and devices for sustained drug delivery. The compositions can include a fluid carrier; a plurality of first polymeric microparticles having a bioactive agent dispersed in the fluid carrier; and a plurality of second polymeric microparticles having a visualization agent dispersed in the fluid carrier with the first microparticles. Alternative compositions can include: a fluid carrier; and a plurality of polymeric microparticles having a bioactive agent encapsulated therein and a visualization agent on a surface of the polymeric microparticles, the plurality of polymeric microparticles being dispersed in the fluid carrier. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle apparatus oscillating at 10-12000 minutes per minutes at an amount of 1.0E-03 mL to 1.0E-16 mL per injection.

Compositions, methods and devices for local drug delivery

An intracorporeal marker for marking a site within living tissue of a host having a body of porous hydroxyapatite whose physical properties permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities.

Growing community of inventors

Phoenix, AZ, United States of America

Chandrashekhar Prabhakar Pathak