Biocon Limited

Chandrashekar Aswathanarayanappa

Sambasivam Ganesh

Madhavan Sridharan

Tom Thomas Puthiaparampil

Acharya Poornaprajna

Venkata Srinivas Pullela

Dharshan Jakkali Chandregowda

Kothakonda Kiran Kumar

Srinivas Pullela Venkata

Chandrasekhar Duvva

Reena Vijayaraghavan

The present disclosure relates to processes for the preparation of 2-amino-1,3-propane diol compounds and their hydrochloride salts. Particularly, the present disclosure relates to processes for synthesizing 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol and its hydrochloride salt 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride respectively. The said process is safe, commercially feasible for large-scale synthesis and has improved efficacy along with many other advantages. The present disclosure also relates to the novel polymorphs of 2-amino-1,3-propane diol compound and its hydrochloride salt, where in 2-amino-1,3-propane diol compound is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol, and its hydrochloride salt is 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride.

Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof

The present invention relates to methods of synthesizing oligomeric compounds, and more particularly, to methods of synthesizing oligomer compounds comprising polyethylene glycol moieties. The present invention provides improved methods for synthesizing oligomers comprising polyethylene glycol moieties. Methods according to embodiments of the present invention may utilize reaction conditions that are milder, efficacious than those taught by conventional methods.

Method of synthesizing a substantially monodispersed mixture of oligomers

In one aspect, the invention provides a process for the preparation of compounds of Formula I  

Process for stereoselective reduction of &#x3b2;-ketoesters

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Chandrashekar Aswathanarayanappa