Council of Scientific & Industrial Research

Chandrasekhar Srivari

Prathama Satyendra Mainkar

Pavan Kumar Togapur

Somesh Sharma

Srigiridhar Kotamraju

Chada Raji Reddy

Subbarao Mohan Venkata Muppidi

Srinu Paladugu

Sukumar Genji

Ashok Kumar Jha

Satyendra Mainkar Prathama

Kranthi Kumar Ramagonolla

Prem Kumar Arumugam

Subbarao Mohan Muppidi

The present invention relates to a process for the preparation of tapentadol and analogs or compounds or stereoisomers of formula (I), Formula I wherein, A is aryl, heteroaryl, and cycloalkyl; R is H, OH, OR, halogen, C-Calkyl, cycloalkyl, aryl or heteroaryl; Ris C-Calkyl, cycloalkyl, aryl or heteroaryl, wherein each of these groups may further be substituted with one or more substituent selected from H, OH, halogen, CN, NO, C-Calkyl or phenyl. Further, the multi-step process involves no column chromatography purification until the very last step. This makes this process highly commercially viable and industrially useful.

Process for the preparation of tapentadol and analogs thereof

Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R, R, R, R, R, and Rare hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Indole (sulfomyl) n-hydroxy benzamide derivatives as selective HDAC inhibitors

The present invention relates to a process for the preparation of (1-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C&#x2014;H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by SpC&#x2014;H activation, reductive hydrogenation and amidation.

Process for the preparation of Zafirlukast and analogs thereof

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Telangana, India

Chandrasekhar Srivari