Bigtec Private Limited

Chandrasekhar Bhaskaran Nair

Pillarisetti Venkata Subbarao

Mulakkapurath Narayanan Manoj

Madhuri Baliga

Kirubakaran Naveen Kumar

Sathyadeep Viswanathan

Renjith Mahiladevi Radhakrishnan

Raviprakash Jayaraman

Venkata Ramachandra Rao Vasamsetty

Kishore Krishna Kumar

Phani Kumar Pullela

Sudip Mondal

Sankaranand Kaipa Narasimha

Manjula Jagannath

Manoj Mulakkapurath Narayanan

Shilpa Chennakrishnaiah

Venkataraman Venkatakrishnan

Gopalakrishna Mangalore Kini

Santhosh Kumar Gandhavalla

Mitchell Preetham Pinto

Swetha Chandra

Phanikumar Pullela

Gopalkrishna Mangalore Kini

Venkatakrishnan Venkataraman

The present disclosure provides a cartridge for purifying biological samples. The cartridge comprises a first chamber configured to receive and hold biological samples, and at least one second chamber configured to receive and hold a reagent solution. A first fluid flow control valve is fluidly connected to outlet ports of the first chamber and the at least one second chamber. Also, the first fluid flow control valve is fluidly connected to a matrix chamber and is configured to selectively route biological samples and reagent solution into the matrix chamber for purifying the biological samples. A binding matrix is configured in the matrix chamber for capturing the nucleic acids from the biological samples and the reagent solution. Further, a elute collection chamber is fluidly connected to the matrix chamber, wherein the elute collection chamber is configured to receive and hold purified biological sample from the matrix chamber.

Cartridge for purification of biological samples

The present disclosure provides a portable device for purifying biological sample. The device comprises a housing and a cartridge holder accommodated in the housing for holding at least one cartridge configured to purify the biological sample. At least one pump is positioned in the housing which is fluidly connectable to the cartridge to circulate the sample and one or more fluids through the cartridge. Further, at least one heating element is configured to heat a matrix chamber in the cartridge. At least one actuator is disposed in the housing to actuate one or more valves to selectively route the biological sample and the one or more fluids in the cartridge. A control unit is interfaced with the actuator, the heating element and the pump and is configured to regulate operation of the actuator, the pump and the heating element during purification of the biological sample.

Portable device for purifying biological sample and a method thereof

The present disclosure provides a non-contact real time micro Polymerase Chain Reaction (PCR) system comprising; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising an associated LED driver and a photo detector amplifier placed above the chip to detect fluorescence; an induction heater mounted around the chip and inductively coupled to the metal heater; an infrared temperature sensor mounted below the chip for measuring a temperature of the metal heater, wherein the infrared temperature sensor is interfaced with a signal conditioner; and a controller interfaced with the signal conditioner and the induction heater for regulating the power to the induction heater based on feedback received from the infrared temperature sensor through the signal conditioner.

Non contact real time micro polymerase chain reaction system and method thereof

Instant invention is about a hand held micro PCR device comprising a LTCC micro PCR chip comprising a heater, a reaction chamber to load a sample. It also comprises a heater control to regulate the heater on basis of input received from a temperature sensor. It further has an optical system having an optical fiber to detect a fluorescence signal from the sample, and at least one communication interface to interact with other device(s).

Hand held micro PCR device including microcontroller for exchanging information with a communications interface

In one aspect, methods relate to the field of recombinant DNA therapeutics. Methods may involve bio-informatics design, synthesis of artificial genes for a human insulin precursor having a leader peptide coding sequence, cloning artificial genes into an expression vector, and expression in an organism such as one selected from the genus. In another aspect, methods may include downstream processing for obtaining protein precursor molecules and subsequent conversion of protein precursor molecules to functional proteins.

Method of downstream processing for conversion of human insulin precursor molecule into a functional human insulin protein molecule

Polynucleotide and polypeptide sequence and methods thereof

The present invention relates to a biofuel composition comprising normal chain alcohol(s), natural oils and diesel optionally along with fuel additive(s); a process of preparation and a method of fueling said biofuel composition.

Biofuel composition, process of preparation and a method of fueling thereof

Instant invention is about a micro chip comprising plurality of layers of LTCC wherein a reaction chamber is formed in plurality of top layers to load samples. A heater embedded in at least one of the layers below the reaction chamber and a temperature sensor is embedded in at least one of the layers between the heater and the reaction chamber for analyzing the sample. The temperature sensor can be placed outside the chip to measure the chip temperature.

Micro chip

The present disclosure provides a method to isolate natural & artificial nucleic acids like deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and peptide nucleic acid (PNA) from a solid or liquid sample using cotton. The cotton packed is such that, a solution containing nucleic acids passes through it and the nucleic acids in solution are bound to the cotton in a medium optimal for binding. The nucleic acids are bound to cotton in such a way that, the bound nucleic acids can withstand multiple washes with liquid comprising water and gets eluted in an aqueous buffer, with which eluted nucleic acids can be directly used for amplification using PCR or for any other biochemical or molecular biology needs.

Method for isolation of nucleic acids and a kit thereof

The present disclosure relates to a field of recombinant DNA therapeutics. It involves the bio-informatics design, synthesis of artificial gene for human insulin precursor including leader peptide coding sequence, cloning in an expression vector and expression in an organism, preferably. The present disclosure also relates to methods of downstream processing for obtaining protein precursor molecules and subsequent conversion of precursor molecules to functional proteins.

The present invention relates to a biofuel composition comprising distilled technical cashew nut shell liquid (DT-CNSL) and atleast one petroleum product optionally alongwith plant oils and fuel additive(s). It also relates to a process for preparation of biofuel composition and a method of fueling biofuel composition.

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Bengaluru, India

Chandrasekhar Bhaskaran Nair