Immunocore Limited

Adaptimmune Limited

Chandramouli Reddy Chillakuri

Dhaval Jaykant Sangani

Graham Anthony Hood

Peter Eamon Molloy

Nathaniel Ross Liddy

Andrew Creese

Arsen Valeryevich Volkov

Stephen Harper

Alex Powlesland

Alina Popa

Ana Pereira Ribeiro

Vijaykumar Karuppiah

Eduardo Mateos-diaz

Arnaud Techine

Emma Grant

Kate Atkin

Pedro Cuadrado Rodenas

Tamara Aleksic

Ana Penas

Nicole Mai

Jakub Jaworski

Martin Ebner

Florence Schlosser

Dhaval Sangani

Benjamin Oestringer

Pietro Dellacristina

Victoria Arena De Souza

Graham Hood

The present invention relates to binding molecules that comprise T cell receptor (TCR) variable domains and which can bind to a PIWIL1 peptide-HLA complex. The invention also relates to the use of such molecules for the treatment of malignant diseases.

Binding molecules

The present invention relates to binding molecules that comprise T cell receptor (TCR) variable domains and which can bind to a PRAME peptide-HLA complex. In particular, the present invention relates to binding molecules that bind to PYLGQMINL (SEQ ID NO: 1) in complex with HLA-A24. The invention also relates to the use of such molecules for the treatment of malignant diseases.

The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain comprising an alpha chain variable domain and a beta chain comprising a beta chain variable domain and the library comprises more than one TRAV gene product and/or more than one TRBV gene product, wherein the beta chain variable domain does not comprise one or more of a TRBV5-1, 5-3, 5-4, 5-5, 5-6, 5-7 or 5-8 gene product and wherein the plurality of TCRs do not consist essentially of TCRs comprising a TRAV12-2 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire and TCRs comprising a TRAV21 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire.

TCR libraries

The present invention relates to novel peptides derived from Kita-kyushu lung cancer antigen (CT83), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.

Peptides derived from Kita-kyushu lung cancer antigen (KKLC1, CT83, CXorf61) and complexes comprising such peptides bound to MHC molecules

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Abingdon, United Kingdom

Chandramouli Reddy Chillakuri