Arizona State University

Chandrabali Bhattacharya

Sidney M Hecht

Rakesh Paul

Manikandadas Mathilakathu Madathil

Michael James Rishel

Trevor Bozeman

Zhiqiang Yu

Chenhong Tang

This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.

Saccharide conjugates

The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.

Sugar-linker-drug conjugates

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Tempe, AZ, United States of America

Chandrabali Bhattacharya