Taimed Biologics, Inc.

Taimed Biologies, Inc.

Chandra Panchal

Brent Richard Stranix

Jean-Francois Lavallee

Guy Milot

Nicolas Leberre

Dominik Herbart

Marco Petrella

Michael Ge

Jinzi J Wu

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein Rmay be, for example, 2-pyridyl-CH&#x2014;, 3-pyridyl-CH&#x2014;, 4-pyridyl-CH&#x2014;, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R&#x2014;CO)&#x2014;, Rbeing selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONRR, CHOH or CHOR.

Protease inhibitors

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein Rmay be, for example, 2-pyridyl-CH&#x2014;, 3 -pyridyl-CH&#x2014;, 4-pyridyl-CH&#x2014;, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R&#x2014;CO&#x2014;, Rbeing selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONRR, CHOH or CHOR.

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Dollard-des-Ormeaux, Canada

Chandra Panchal