Servier Pharmaceuticals LLC

Agios Pharmaceuticals, Inc.

Chandra Agarwal Prakash

Hua Yang

Varsha Venkatachalam Iyer

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a purified compound described herein.

Therapeutically active compounds and their methods of use

Described herein are methods of treating pyruvate kinase deficiency (PKD), sickle cell disease or thalassemia with mitapivat or a pharmaceutically acceptable salt thereof, or use of the drug for the treatment of these conditions, in combination with or in the absence of with a secondary drug, such as an inducer or an inhibitor of cytochrome P450. Various doses and dosing regimens of mitapivat in monotherapy and in concomitant medications are described.

Growing community of inventors

North Andover, MA, United States of America

Chandra Agarwal Prakash