Council of Scientific and Industrial Research

Chandishwar Nath

Anil Kumar Saxena

Anil Kumar Dwivedi

Satyawan Singh

Arvind Kumar Srivastava

Ram Pratap

Ram Raghubir

Zeeshan Fatima

Kuldeep Kumar Roy

Santoshkumar Tota

Rakesh Shukla

Neeraj Shakya

Alok Kumar Verma

Mukesh Srivastava

Amar Bahadur Singh

Himanshu Singh

The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R=alkyl, aryl, substituted aryl; R=H, methyl; R=H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl. 

Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of Alzheimer's disease

The present invention relates to new substituted carbamic acid quinoline-6-yl esters of formulae 1 and 2 where R=alkyl, aryl; R=H, alkyl, aralkyl useful as acetylcholinesterase inhibitors, and which show potent antiacetylcholinesterase activity and have potential therapeutic use for prevention or cure of acetylcholinesterase related disorders including peripheral as well as central nervous system. 

Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors

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Chandishwar Nath