Council of Scientific and Industrial Research

Chandeshwar Nath

Ram Pratap

Suman Preet Singh Khanuja

Madan Mohan Gupta

Dharmendra Saikia

Satyawan Singh

Anil Kumar Gupta

Arvind Kumar Srivastava

Ram Kishor Verma

Santosh Kumar Srivastava

Anil Kumar Rastogi

Ramesh Chander

Sudhir Srivastava

Anju Puri

Anirban Pal

Raghwendra Pal

Ram Raghubir

Subhash Chandra Singh

Hemant Kumar Singh

Janardan Singh

Onkar Prasad Asthana

Nitya Nand

Anupam Maurya

Narenda Singh

Puvvada Sri Ramachandra Murthy

Arwind Kumar Srivastava

Depak Raina

Girja Shankar

Shipra Srivastava

Kalpana Bhandari

Ashok Kumar Agrawal

Brajendra Kumar Tripathi

Priti Tiwari

Mavurapu Satyanarayana

Vinay Kumar Khanna

Shikha Gupta

Dnyaneshwar Umrao Bawankule

The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and &#x3b1;-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds &#x3b1;-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 

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The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents

The present invention provides N-aryloxypropanolyl-N'-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesitywherein R is selected from the group consisting of H, 2, 3 or 4-trifluoromethyl, 2, 3, or 4-chloro, 2, 3, or 4-bromo, 4-acetyl, 4-propionyl, 4-acetamido, 2,3 or 4 methoxy, 4 nitrile, 2,3 or 4-methyl, and 4 formyl and X is S or O.

N-aryloxypropanolyl-N'-phenethyl-urea

The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Method of treating a cognitive memory dysfunction using Gugulipid

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Lucknow, India

Chandeshwar Nath