Industry Academic Cooperation Foundation Hallym University

Republic of Korea Represented by Rural Developement Administration

Chan Hum Park

Jin Pil Kim

Seok Jong Kang

Kwang Gill Lee

Joo Hong Yeo

You Young Jo

Hae Yong Kweon

Soon Hee Kim

Young Jin Lee

Jang Min Kim

Oh Jun Kwon

Han Na Lee

Md Tipu Sultan

Chun Hwoi Kim

Ji Ye Kim

Ji Won Heo

Sang Mi Han

Soon Ok Woo

Olatunji Abolarin Ajiteru

Ok Joo Lee

Sang-Mi Han

Ji Seung Lee

Seok Woo Kang

The present disclosure relates to the composition and process for the production of an ultra-strong, biocompatible, electroconductive, and stretchable hydrogel, which comprises: a step (a) of physical or chemical modification of natural polymers e.g., preparation of silk nanofiber and double methacrylation of gelatin; a step (b) of graphene oxide (GO) carboxylation; a step (c) of carbodiimidation between methacrylated natural polymers of step (a) and carboxylated GO of step (b); and a step (d) of three dimensional (3D) bioprinting of step (c) with/without silk nanofiber. It was found that these steps in this disclosure give rise to a biocompatible hydrogel with high mechanical strength in the range of load-bearing soft tissue such as tendon and heart as opposed to conventional hydrogels.

Photo-curable bioink to fabricate ultra-strong, electroconductive, and biocompatible hydrogel for regenerative medicine

Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

Artificial eardrum using silk protein and method of fabricating the same

Growing community of inventors

Chuncheon-si, South Korea

Chan Hum Park