Korea Advanced Institute of Science and Technology

Korea Railroad Research Institute

Intelligent Synthetic Biology Center

Chan Bae Park

Sun Chang Kim

Soon Jang Lee

Hyung-Chul Kim

Hyung-Woo Lee

Yong-Hyeon Cho

Sam-Young Kwon

In Yup Park

Dong-Wook Jang

The present invention relates to a method for screening an activator of mitochondrial activity by using gypenoside-treated cells, to a composition for screening an activator of mitochondrial activity, comprising the gypenoside, and to a kit comprising the composition. By using the method for screening an activator of mitochondrial activity of the present invention, it is possible to effectively discover a preparation which can substantially promote the mitochondrial activity, and thus the method is expected to be widely used in developing a therapeutic agent for diseases caused by mitochondrial activity inhibition.

Method for screening activator of mitochondrial activity

Provided is a tube railway system that reduces noise and air resistance using a sealed evacuated tube as a passage for a tube railway, thereby allowing a train to run at a higher speed. A vacuum division management system and a vacuum blocking screen device for a tube railway system required to maintain vacuum are provided, in which the vacuum blocking screen device is operated to rapidly block a passage for a tube railway in response to an operation signal, is installed at every certain section or at a designated section of the tube railway, and is operated in a specific section when a vacuum maintenance problem occurs, or when the vacuum needs to be released, or when the train needs to stop immediately, thereby allowing the specific section to be isolated from other sections to have a degree of vacuum different from those of the other sections.

Vacuum division management system and vacuum blocking screen device for tube railway system

Disclosed is a novel antimicrobial peptide, named parasin I, which is isolated from catfish. Catfish produce a strong antimicrobial peptide in the epithelial mucosal layer upon epidermal injury to protect against the invasion of microorganisms. It is 2000.4 Da in molecular mass and consist of 19 amino acid residues, represented by Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser (SEQ ID NO: 1) Parasin I shows exceptionally potent antimicrobial activity against a broad spectrum of micrroorganisms, including Gram-positive and Gram-negative bacteria and fungui, without any hemolytic activity. Its synthetic derivatives also have potent activity. Therefore, parasin I and its derivatives can be used as wound healing agent, trauma curing agent, mouthwash, eyewash, etc.

Antimicrobial peptide isolated from parasilurus asotus and its uses

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Gyeonggi-do, South Korea

Chan Bae Park