Centre National De La Recherche Scientifique

Aventis Pharma S.a.

Newvectys

Université Pierre Et Marie Curie

Chamsy Sarkis

Jacques Mallet

Che Serguera

Nicolas Grandchamp

Noelle Dufour

Dorothee Altemir

Stéphanie Philippe

Stephanie Philippe

Yi He

The present invention describes a recombinant retroviral vector which cannot by itself achieve complete reverse transcription as well as its uses, in particular for transiently transferring in vitro, ex vivo or in vivo at least one ribonucleic acid sequence of interest in a cell. Such a transient transgene expression is of interest in the context of research, therapy and more generally in the field of biotechnology.

Transient expression vectors, preparation and uses thereof

The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.

Non-integrative and non-replicative lentivirus, preparation and uses thereof

The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.

Methods of gene transfer to astrocytes with mokola virus pseudotyped lentivirus vectors

The invention concerns novel recombinant viruses and their use for gene-transfer into nerve cells of vertebrates. The invention also concerns pharmaceutical compositions comprising said recombinant viruses. More particularly, the invention concerns novel vectors derived from baculoviruses and their use for treating diseases of the nervous system of vertebrates.

Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates

Growing community of inventors

Boulogne Billancourt, France

Chamsy Sarkis