Enterome

Irix Pharmaceuticals, Inc.

Patheon Api Services Inc.

Lund Biotechnology Pbc

Chaminda Priyapushpa Gamage

George Yiannikouros

Panos Kalaritis

Denis Viktorovich Arefyev

Michael P Cruskie, Jr

Stephanie Bosse Abernathy

Joseph Chase Chewning

Marc Labelle

George Petros Yiannikouros

Denis Arefyev

The invention relates to a process to prepare a compound of the following formula (I): (I), in which P represents a protective group of a hydroxyl function which is a &#x2014;CORgroup with Rrepresenting an aryl or a (CC)alkyl, R represents a hydrogen atom or a protective group of a terminal alkyne, from mannose, comprising the following steps: (a) protecting the 5 hydroxyl groups of the mannose by a protective group P; (b) coupling the protected mannose obtained at step (a) with a compound of the following formula (II). The present invention also relates to a compound of formula (IIIa). 

Process for preparing mannose derivatives

Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of the prostaglandins and prostaglandin analogs.

Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis

The presently disclosed subject matter provides methods of preparing synthetic prostacyclin analogs, including Beraprost, either as racemic mixtures or as single stereoisomers. Also provided are novel synthetic intermediates for use in these methods.

Process for preparing synthetic prostacyclins

The presently disclosed subject matter provides a method of synthesizing prostaglandins and prostaglandin analogs comprising the ring closing metathesis of compounds of Formula (I). Also provided are novel compounds of Formula (I) and Formula (II). In addition to their use as synthetic intermediates in the presently disclosed methods, compounds of Formula (II) can be used as prostaglandin and/or prostaglandin analog prodrugs.

Synthesis of prostanoids

Growing community of inventors

Florence, SC, United States of America

Chaminda Priyapushpa Gamage