Leland Stanford Junior University

Probiusdx, Inc.

Chaitanya Gupta

Roger T Howe

Emmanuel Philippe Quevy

Boris Murmann

Jeremy Hui

Ross M Walker

Mehdi Javanmard

Sam Emaminejad

Ross Walker

An all-electronic high-throughput detection system can perform multiple detections of one or more analyte in parallel. The detection system is modular, and can be easily integrated with existing microtiter plate technologies, automated test equipments and lab workflows (e.g., sample handling/distribution systems). The detection system includes multiple sensing modules that can perform separate analyte detection. A sensing module includes a platform configured to couple to a sample well. The sensing module also includes a sensor coupled to the platform. The sensing module further includes a first electrode coupled to the platform. The first electrode is configured to electrically connect with the sensor via a feedback circuit. The feedback circuit is configured to provide a feedback signal via the first electrode to a sample received in the sample well, the feedback signal based on a potential of the received sample detected via a second electrode.

All-electronic high-throughput analyte detection system

A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte.

Nanoscale electrochemical interface for detection of analytes

A high-gain and low-noise negative feedback control ('feedback control') system can detect charge transfer in quantum systems at room temperatures. The feedback control system can attenuate dissipative coupling between a quantum system and its thermodynamic environment. The feedback control system can be integrated with standard commercial voltage-impedance measurement system, for example, a potentiostat. In one aspect, the feedback control system includes a plurality of electrodes that are configured to electrically couple to a sample, and a feedback mechanism coupled to a first electrode of the plurality of electrodes. The feedback mechanism is configured to detect a potential associated with the sample via the first electrode. The feedback mechanism provides a feedback signal to the sample via a second electrode of the plurality of electrodes, the feedback signal is configured to provide excitation control of the sample at a third electrode of the plurality of electrode.

Mesoscale system feedback-induced dissipation and noise suppression

Aspects of a biosensor platform system and method are described. In one embodiment, the biosensor platform system includes a fluidic system and tunneling biosensor interface coupled to the fluidic system. The tunneling biosensor interface may include a transducing electrode array having at least one dielectric thin film deposited on an electrode array. The biosensor platform system may further include processing logic operatively coupled to the transducing electrode array. In operation, the application of an electromagnetic field at an interface between an electrode and an electrolyte in the system, for example, may result in the transfer of charge across the interface. The transfer of charge is, in turn, characterized by electromagnetic field-mediated tunneling of electrons that may be assisted by exchange of energy with thermal vibrations at the interface. Various analytes, for example, and other compositions can be identified by analysis of the transfer of charge.

Sensing platform for transduction of information

Embodiments of the present disclosure provide for systems of enhancing the signal to noise ratio, methods of orienting a nanomaterial (e.g., an antibody), methods of enhancing the signal to noise ratio in a system (e.g., an assay system), and the like.

Methods and systems for orienting nanomaterials

A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed. One or more of a resonant exchange of energy between one or more electrons exchanged by the metal and the electrolyte and vibrating bonds of a molecular analyte, for example, may be sensed by measuring small signal conductivity of an electrochemical interface.

Sensing platform for quantum transduction of chemical information

Aspects of a biosensor platform system and method are described. In one embodiment, the biosensor platform system includes a fluidic system and tunneling biosensor interface coupled to the fluidic system. The tunneling biosensor interface may include a transducing electrode array having at least one dielectric thin film deposited on an electrode array. The biosensor platform system may further include processing logic operatively coupled to the transducing electrode array. In operation, the application of an electromagnetic field at an interface between an electrode and an electrolyte in the system, for example, may result in the transfer of charge across the interface. The transfer of charge is, in turn, characterized by electromagnetic field-mediated tunneling of electrons that may be assisted by exchange of energy with thermal vibrations at the interface. By analysis of the transfer of charge, the identify of various analytes, for example, or other compositions.

Growing community of inventors

Foster City, CA, United States of America

Chaitanya Gupta