Abic Ltd.

Chaim Simonovitch

Raphael R Haber

Morris E Stolar

Sabar Sasson

Theodor Hoffman

The present invention relates to a process for the preparation of benzothiazepine derivatives of general formula I ##STR1## wherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general formula II ##STR2## in which R has the same meaning as above is reacted with 2-(dimethylamino)-ethyl chloride in a biphasic system of water and a non-combustible aliphatic polychlorinated hydrocarbon solvent in the presence of calcium hydroxide or of barium hydroxide. The process is advantageously performed at a temperature between 15.degree. and the refluxing temperature of the aliphatic polychlorinated hydrocarbon solvent. The process is optionally performed in the presence of a suitable quaternary ammonium halide. In the process the amount of calcium hydroxide or barium hydroxide is advantageously 1-3 moles per 1 mole of the compound of general formula II, the amount of aliphatic polychlorinated hydrocarbon solvent is advantageously 15-40 ml and that of water 3-10 ml per g of the compound of general formula II and the ratio aliphatic chlorinated hydrocarbon solvent:water is advantageously 2:1 to 10:1.

Process for the preparation of benzothiazepine derivatives

The invention provides new hexahydro-1,2,4-triazine-3,5-dione derivatives having anticoccidiastatic activity, to the production thereof and to their use as part of a feed and/or pre-feed mixture.

Hexahydro-1,2,4-triazine-3,5 dione derivatives

The present invention deals with derivatives of quinoxaline-1,4-dioxides, processes for their preparation and their utility, inter alia, as pharmaceutical compositions for the treatment of infectious diseases as well as their use as antiseptic agents. Moreover said compounds show a good growth promoting effect in animals.

Derivatives of quinoxaline-1,4-dioxides

The present invention deals with derivatives of naphthyridine, process for their preparation and their utility, inter alia, as anti-bacterides and as feed-additives.

Derivatives of naphthyridine

This invention relates to anti-inflammatory pyridone derivatives, particularly 2,6-dimethyl-1,4-dihydro-4-oxo-3,5 pyridine-dicarboxylates and derivatives thereof which have an anti-inflammatory action, as well as compositions therewith, use of these compounds for their anti-inflammatory effect, and production thereof. These 4-oxo pyridines of the present invention, refer to in the literature as 4-(1H)-pyridones are suitably prepared by reacting a 2,6-dimethyl-4-oxo 3,5 pyrone-dicarboxylate with an aniline in an acidic medium such as acetic acid.

Phenylene bis-N,N'(pyridones)

There are disclosed water-soluble compositions comprising a 1,3-bis-[(p-chlorobenzylidene)-amino]-guanidine (called Robenidine) salt, particularly the hydrochloride. Said compositions comprise also a suitable water-soluble organic solvent and a suitable water-soluble solubilizer; the solvent and the solubilizer being miscible with each other. There are also disclosed aqueous solutions comprising the above composition and a method for the treatment of animals being infected with Cocciodiosis with said aqueous solution.

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Rishon Letzion, Israel

Chaim Simonovitch