Johns Hopkins University

Mayo Foundation for Medical Education and Research

Buck Institute for Research on Aging

Unity Biotechnology, Inc.

Chaekyu Kim

Alain Philippe Vasserot

Nathaniel E David

Jennifer H Elisseeff

Judith Campisi

Remi-Martin Laberge

James L Kirkland

Tamar Tchkonia

Marco Demaria

Yi Zhu

Jan M A Van Deursen

Darren J Baker

Bennett G Childs

Albert Davalos

Okhee Jeon

Jan MA Van Deursen

This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone).

Treatment of joint pain

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2

Treatment for osteoarthritis by intra-articular administration of a cis-imidazoline

Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells

Growing community of inventors

Pikesville, MD, United States of America

Chaekyu Kim