Council of Scientific and Industrial Research

Council of Scientific and Industrial Research, an Indian Registered Body Incorporated Under Regn. of Soc. Act (act Xxi of 1860)

Chada Raji Reddy

Prathama Satyendra Mainkar

Somesh Sharma

Srivari Chandrasekhar

Srihari Pabbaraja

Sistla Ramakrishna

Chandrasekhar Srivari

Subhash Ghosh

Pavan Kumar Togapur

Srigiridhar Kotamraju

Avula Shiva Krishna

Gangarajula Sudhakar

Kumaraguru Thenkrishnan

Rajesh Nasam

Prem Kumar Arumugam

Subbarao Mohan Venkata Muppidi

Ashok Kumar Jha

Kuncha Madhusudana

Subbarao Mohan Muppidi

Prathama S Mainkar

Andugulapati Sai Balagi

Tirunavalli Satya Krishna

Muppidi Mohan Venkata Subbarao

The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

Chemo-enzymatic process for the preparation of homopropargylic alcohol

Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R, R, R, R, R, and Rare hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Indole (sulfomyl) n-hydroxy benzamide derivatives as selective HDAC inhibitors

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Telangana, India

Chada Raji Reddy