Council of Scientific & Industrial Research

Chada Raji Reddy

Prathama Satyendra Mainkar

Somesh Sharma

Srivari Chandrasekhar

Srihari Pabbaraja

Chandrasekhar Srivari

Subhash Ghosh

Srigiridhar Kotamraju

Pavan Kumar Togapur

Prem Kumar Arumugam

Avula Shiva Krishna

Subbarao Mohan Venkata Muppidi

Gangarajula Sudhakar

Kumaraguru Thenkrishnan

Ashok Kumar Jha

Rajesh Nasam

Subbarao Mohan Muppidi

The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

Chemo-enzymatic process for the preparation of homopropargylic alcohol

Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R, R, R, R, R, and Rare hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Indole (sulfomyl) n-hydroxy benzamide derivatives as selective HDAC inhibitors

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Telangana, India

Chada Raji Reddy