University of Kansas

Stc.unm

University of Louisville Research Foundation, Inc.

Southern Research Institute

St. Unm

Chad Schroeder

Jennifer Elizabeth Golden

Jeffrey Aube

Larry A Sklar

Tuanli Yao

Angela Wandinger-Ness

Zurab Surviladze

E Lucile White

Denise S Simpson

Donghoon Chung

Nichole A Tower

Jacob Ongudi Agola

Bruce S Edwards

Richard Smith Larson

Tudor Oprea

Warren S Weiner

Laurie Hudson

Jeffrey Aubé

Irena Ivnitski-Steele

Hadya M Khawaja

Jerec Warren Ricci

Julica J Noth

Juan Jacob Strouse

The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV). 

6-substituted quinazolinone inhibitors

The present invention relates to molecules which function as selective modulators (i.e., inhibitors and agonists, preferably inhibitors) of the Ras-homologous (Rho) family of small GTPases, in particular, Cdc42 GTPase and their use to treat diseases, for example cancers, including metastatic cancer, where Cdc42 GTPase is overexpressed or hyperactivated, genetic and acquired diseases where activation of Cdc42 GTPase plays a pivotal role (e.g., neurodegenerative diseases), rheumatoid arthritis, atherosclerosis, diabetes type I, autosomal polycystic kidney diease, cystic kidney disease, precystic kidney disease and microbial infections. Additionally, compounds according to the present invention may be used to inhibit rejection (graft host response) in transplant patients (pursuant to transplantation), to promote immunosuppression, anti-inflammatory response and to mobilize stem cell (migration) in patients in need, among others.

Modulators of GTPase and use in relevant treatment

This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.

Rab7 GTPase inhibitors and related methods of treatment

The present invention provides pyrazolo[1,5-a]pyrimidine compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1. Compounds and compositions according to the present invention may be used to treat cancer, including drug resistant (DR) and multiple drug resistant (MDR) cancers.

Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment

Growing community of inventors

Lawrence, KS, United States of America

Chad Schroeder