Novartis Ag

University of Rochester

Chad Eric Bigelow

Thaddeus Peter Dryja

Seshidhar Reddy Police

Vivian Choi

Thomas Foster

Bijan Etemad-Gilbertson

Nicole Haubst

Joy Gispati Ghosh

Allan R Oseroff

Michael Stefanidakis

Stephen Hedrick Poor

Engin Toksoz

Nina Moker

Michael Zbigniew Twarog

Nalini Velamur Rangaswamy

Yubin Qiu

James Edgar Chastain

Andrew Anh Nguyen

Ganesh Rajan Iyer

Shawn Michael Hanks

Kirk Lee Clark

Ana Maria Carrion

William J Cottrell

Joanna Vrouvlianis

Akshata Ninad Gujar

The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and M&#xfc;ller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.

Viral vectors for the treatment of retinal dystrophy

An instrument for photodynamic therapy applies treatment light from a dye laser, white light, and ultraviolet fluorescence excitation light from an LED onto a lesion and surrounding areas in a time-multiplexed manner. The reflected white light is analyzed in a spectrometer to determine a correction for the dynamic optical spectral properties of the patient's tissue. Light emitted by fluorescence from the lesion and the surrounding areas is analyzed in another spectrometer, and the results are corrected in a computer, using the correction. An optical switch has been developed for the instrument, using a bistable solenoid and a sled.

Photodynamic therapy with spatially resolved dual spectroscopic monitoring

Growing community of inventors

Somerville, MA, United States of America

Chad Eric Bigelow