Battelle Memorial Institute

Medrad, Inc.

Nike, Inc.

Iowa State University Research Foundation Inc

Abbott Laboratories Corporation

Baxter International Inc.

Baxter Healthcare Sa

Neoprobe Corporation

Cardinal Health 414, LLC

Bayer Healthcare LLC

Hudson Respiratory Care, Inc.

Battelle Pulmonary Therapeutics, Inc.

Nike International Ltd.

Nike Innovate C.v.

Chad Edward Bouton

Gaurav Sharma

Jeffrey A Friend

Nicholas Annetta

Jeffrey Richard Held

John T Stites

Carl L Madore

Raymond J Sander

Gary Gene Tavares

Steven Risser

Amy M Heintz

Thomas D Haubert

James E Dvorsky

Jeffrey Alan Hadden

Gregory S Kramer

Kenneth G McConnell

George Brand

Andrew Sweeney

Stephanie Kute

Clifford N Dodson

Matthew Edward Mowrer

Patrick K Hoffman

Raymond Richard Zaborski

Alan D Hirschman

Ramanathan S Lalgudi

Alexander Morrow

David A Friedenberg

David Arthur Holley

Garrick L Maenle

Clark E Fortney

Mehmet Husnu

James B Gleeson

Steven R Nelson

Dale M Radcliff

Mike Kelly

Felicia R Ruggeri

William Godwin Atterbury

Herman P Benecke

Daniel B Garbark

James A Prescott

Bradley Charles Glenn

Thomas Alan Klausing

Jeffrey L Ellis

Scott Nicholas Danhof

R Reade Harpham

John Bartholomew

Daniel A Kramer

Eric Hassenpflug

Brian Charles Kelley

Rachel Thurston

Joseph Edward Zambanini

Jeffrey Taylor Stroup

Dennis Eshima

Derrick Alcaide

James Stone

Henry Padgett

Arthur E Uber, Iii

Gregory A Trees

Jan B Yates

Roger W Smith

Joseph A Juratovac

Larry McCutchan

Francis J Sciulli, Jr

Richard D Peters

Dennis P Hack

William C Zimlich

David R Busick

Marc A Mabie

Peter Andrew Gaydos

C Alexander Morrow

Michael L Kelly

Jeffrey R Held

Charles J Mutschler

Carl Madore

Daniel Duane Meek

Garrick L Meanle

Richard C Mayoras, Jr

Jeffery R Held

Jeffrey Friend

Jeffrey A Hadden

Steven M Risser

Daniel D Meek

The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Neural sleeve for neuromuscular stimulation, sensing and recording

The present disclosure relates generally to systems, methods, and devices for interpreting neural signals to determine a desired movement of a target, transmitting electrical signals to the target, and dynamically monitoring subsequent neural signals or movement of the target to change the signal being delivered if necessary, so that the desired movement is achieved. In particular, the neural signals are decoded using a feature extractor, decoder(s) and a body state observer to determine the electrical signals that should be sent.

Systems for neural bridging of the nervous system

A system and method enhance clinical effectiveness for monitoring for a change in a level of fluid in tissue by using a device attached to a body portion that wirelessly reports to a remote apparatus or receiver a current received power level for indications of extravasation or infiltration. Adjusting an activation rate of fluid detection, reporting or both extends service life of the device.

Distributed extravasation detection system for fluid change and to control the fluids levels in a body via wireless interface based on rate of activation

Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals

An integrated device of a patch and sensor assembly detects extravasation or infiltration. A transmitter is positioned to direct power into a body portion. A sensor is positioned to receive the power transmitted through the body portion. A substrate is attachable to an outer surface of the body portion and supports the transmitter and the sensor. A signal processor is coupled to the transmitter and the sensor for detecting a change in a fluid level in the body portion from extravasation or infiltration based on the power received by the sensor. A power supply is coupled to the transmitter and the sensor. An indicator is responsive to the signal processor to indicate a detected change in a fluid level in the body portion from extravasation or infiltration.

Integrated extravasation and infiltration detection device on a RF isolated flexible substrate with fluid guide to detect fluid changes via signal comparison

The present disclosure describes systems, methods, devices for performing thought-controlled neuromuscular stimulation. Also described are methods for producing a neuromuscular stimulation cuff. The systems and methods generally relate to receiving and processing thought signals indicative of an intended action, and then delivering stimulation to effectuate the intended action through a neuromuscular stimulation cuff. The neuromuscular stimulation cuff includes a flexible printed circuit board having at least one finger and a plurality of electrogel discs disposed on the at least one finger. The neuromuscular stimulation cuff may be produced by providing a layer of polyimide, etching a conductive copper circuit including a plurality of electrodes into the layer of polyimide to form an etched circuit layer, adhering a cover layer onto the etched circuit layer to form a flexible printed circuit board (PCB), and cutting at least one finger from the flexible PCB. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Neurostimulation or electromyography cuff

A system detects extravasation or infiltration by segregating active components that drive a passive sensor for economical single use. A receiving antenna of the passive sensor receives a transmitted signal comprising RF electromagnetic power. A first circuit transmits a first portion of the received signal through a body portion. A sensor detects a resultant signal from the body portion. A second circuit combines a reference signal comprising a second portion of the received signal with the resultant signal so as to define an output signal. A transmit antenna transmits the output signal to a receiver.

Wireless and power-source-free extravasation and infiltration detection sensor circuitry provided on a substrate with signal splitter

Systems and methods for neural bridging of the nervous system

A chronically implanted medical device is disclosed that has an outermost layer formed from a conjugate of a polymer with lipoic acid, the conjugate having free 1,2-dithiolane groups. It is contemplated that this layer scavenges reactive oxygen species, i.e. acts as an antioxidant, and thus reduces inflammation and other adverse effects around the implant itself.

Implant with reactive oxygen species scavenging coating

Extravasation and infiltration detection device with fluid guide provided on a substrate of the detection device to adjust fluid rate based on detection signal

The present disclosure relates generally to systems, methods, and devices for closed loop deep brain stimulation. In particular, a neural signal is measured and provided to software. The software includes a feature generator and a brain network model that takes the neural signal and estimates other neural signals that are not directly measured, and operates as a model of the brain. The software determines a stimulation signal to be sent to stimulating electrodes. Estimated signals by the brain network model are continuously compared to actual signals from the brain. The closed loop feedback system advantageously allows for electrical stimulation levels and patterns to be continuously updated while delivered to a patient.

Closed loop deep brain stimulation systems and methods

Distributed extravasation detecton system

Systems including neuromuscular stimulation cuff

Growing community of inventors

Powell, OH, United States of America

Chad Edward Bouton