University of Michigan

Other

Pfizer Corporation

Chad Alan Van Huis

Gary D Glick

Christopher Franklin Bigge

Jeremy John Edmunds

Kevin James Filipski

Agustin Casimiro-Garcia

Danette Andrea Dudley

Jeffrey Thomas Kohrt

Peter Laurence Toogood

Clarke Bentley Taylor

Alexander Ross Hurd

The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

Benzodiazepinone compounds and methods of treatment using same

The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.

1,4-benzodiazepinone compounds and their use in treating cancer

The present invention provides compounds of Formula (I): wherein A, B, C, G, and Whave any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.

Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade

The present invention provides compounds of Formula (I):wherein A, B, C, G, and Whave any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.

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Plymouth, MI, United States of America

Chad Alan Van Huis