Metabolic Explorer

Céline Raynaud

Philippe Soucaille

Rainer Figge

Michel Chateau

Laurence Dumon-Seignovert

Fabien Lux

Nadège Dumoulin

Olivier Tourrasse

Wanda Dischert

Gwénaëlle Bestel-Corre

Gwenaëlle Corre

Pascale Aliprandi

Gwénaëlle Corre

Laetitia Faure

Emilie Navarro

Gwénaëlle Bestel Corre

Philippe Noel Paul Soucaille

Gwenaëlle Bestel-Corre

Rainer Martin Figge

The present invention concerns a new mutant strain ofcomprising attenuated glycerol kinase activity. In addition, the present invention concerns a consortium ofcomprising at least said mutant strain and at least one other species ofchosen amongand. As this modified strain may be adapted for growth and for the production of 1,3-propanediol in an appropriate culture medium with high glycerol content, the invention also relates to a method for the production of 1,3-propanediolandbutyric acid, by culturing at least this mutant strain in an appropriate culture medium.

Microorganisms with improved 1,3-propanediol and butyric acid production

The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a recombinant microorganism converting glycerol into 1,3-propanediol and overexpressing the hcpR and/or frdX gene on a medium comprising glycerine. A recombinant microorganism for the production of 1,3 propanediol from glycerol, wherein said microorganism converts glycerol into 1,3-propanediol and 10 overexpresses the hcpR and/or the frdX gene.

Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content

The present invention relates to a microbial consortium, especially adapted for growth and production of 1,3-propanediol from a culture medium with high glycerinecontent and specifically with a high concentration of industrial glycerine. More particularly, this microbial consortium comprises at least one strainand at least one strain chosen among strains ofand/or strains of. The invention also relates to a method for the production of 1,3-propanediol by culturing this microbial consortium resulting in a co-culture of these particular different microorganisms.

Microbial consortium for 1,3-propanediol production using high glycerol concentration

The present invention relates to a new method for the production of a molecule of interest by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of molecule of interest, wherein said microorganism comprises functional genes coding PTS carbohydrate utilization system and wherein the expression of proteins regulated the expression of phosphoenolpyruvate synthase (PPS) is down-regulated. The present invention also relates to the genetically modified microorganism used in the method of the invention.

Method for the fermentative production of molecules of interest by microorganisms comprising genes coding sugar phosphotransferase system (PTS)

The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

Conversion of methylglyoxal into hydroxyacetone using novel enzymes and applications thereof

The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.

Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply

A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism.

Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine

The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.

Recombinant enzyme with altered feedback sensitivity

A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives in which production of methionine or derivatives thereof, wherein the microorganism enhances production of cysteine.

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Saint Beauzire, France

Céline Raynaud