Galderma Research & Development

Pfizer Corporation

Cédric Poinsard

Karl Richard Gibson

Pascal Collette

Mark Ian Kemp

Pascale Mauvais

Thibaud Portal

Sharanjeet Kaur Bagal

Sandrine Rethore

Jean-Michel Linget

Laurence Dumais

Stephen Martin Denton

Blanda Luzia Stammen

Melanie Susanne Glossop

The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.

Phenol derivatives and the pharmaceutical or cosmetic use thereof

The present invention relates generally to the field of pharmaceuticals and cosmetics. More specifically, the present invention pertains to certain N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides of the following formula which are potent modulators (e.g., inhibitors) of an androgen receptor, and which are useful, for example, in therapy, for example, in the treatment of a dermatological disease or disorder; a disease or disorder of the sebaceous gland(s); acne; hyperseborrhoea; oily skin; seborrhoeic dermatitis; hyperpilosity or hirsutism; atopic dermatitis; or androgenic alopecia; especially acne. The present invention also relates to compositions (e.g., pharmaceutical compositions, cosmetic compositions) comprising the compounds; methods of preparing the compositions; methods of modulating (e.g., inhibiting) an androgen receptor using the compounds and/or compositions; and medical and/or cosmetic use of the compounds and compositions. 

N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides and their pharmaceutical and cosmetic use

The present invention relates to novel compounds of general formula: and to the cosmetic or pharmaceutical use thereof.

Phenol derivatives and pharmaceutical or cosmetic use thereof

N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides of formula (1) are described that are potent modulators (e.g., inhibitors) of an androgen receptor, and which are useful, for example, in the treatment of a dermatological disease or disorder; a disease or disorder of the sebaceous gland(s); acne; hyperseborrhoea; oily skin, seborrhoeic dermatitis; hyperpilosity or hirsutism; atopic dermatitis; or androgenic alopecia; especially acne. Also described, are compositions (e.g., pharmaceutical compositions, cosmetic compositions) comprising the compounds; methods of preparing the compositions; methods of modulating (e.g., inhibiting) and androgen receptors using the compounds and/or compositions; and medical and/or cosmetic use of the compounds and compositions.

SOAT-1 inhibitors of general formula (I) and cosmetic and pharmaceutical compositions containing such a compound are described.

Dioxo-imidazolidine derivatives, which inhibit the enzyme SOAT-1, and pharmaceutical and cosmetic compositions containing them

Compounds of general Formula (I), and cosmetic and pharmaceutical compositions containing such a compound are described.

Compounds of general Formula (I), and cosmetic and pharmaceutical compositions including such a compound are described.

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Le Plan de Grasse, France

Cédric Poinsard