Metabolic Explorer

Carbios

Evonik Degussa Gmbh

Metabolic Exployer

Metalbolic Explorer

Cédric Boisart

Philippe Soucaille

Rainer Figge

Alain Marty

Michel Chateau

Gwénaëlle Bestel-Corre

Guillaume Barbier

Wanda Dischert

Perrine Vasseur

Benjamin Gonzalez

Emmanuel Maille

Olivier Zink

Guillaume Letellier

Gwenaelle Bestel-Corre

Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.

Increasing methionine yield

The invention relates to a method for recycling at least one plastic product, the method comprising degrading at least one polymer of the plastic product to monomers using an enzyme and recovering the resulting monomers. The method of the invention may be used for degrading, simultaneously or sequentially, at least two different polymers of the plastic product, and/or for recycling at least two plastic products.

Method for recycling plastic products

The invention concerns a microorganism which is genetically modified so as to i) synthesize an organic monomer by fermentation of a carbon source, and ii) depolymerize a polymer constituted at least by an organic monomer which it is capable of synthesizing. The invention also concerns a method for producing an organic monomer using a genetically modified microorganism of this type, as well as the coculture of this microorganism with another microorganism which is capable of synthesizing a polymer of interest.

Recombinant microorganism

The present invention concerns a method for the biological preparation of prenol comprising culturing a microorganism genetically modified for the bioproduction of prenol, wherein the microorganism comprises a metabolic pathway for conversion of 3-methylcrotonyl-CoA into prenol by the action of an alcohol dehydrogenase enzyme and of an aldehyde dehydrogenase enzyme.

Biosynthesis pathway for prenol in a recombinant microorganism

The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to &#x3b1;-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.

Strains and method for the production of methionine

The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite. The invention also concerns a modified microorganism for the production of an aliphatic diol.

Method for the preparation of diols

The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.

Increasing NADPH availability for methionine production

The present invention concerns a modified microorganism for the biological preparation of an hydroxy acid of formula (I) The invention also concerns a method for the fermentative production of a hydroxy acid.

Method for the preparation of hydroxy acids

A microorganism genetically modified for the bioproduction of 1,3-propanediol from sucrose, wherein the microorganism includes: A method for the biological preparation of 1,3-propanediol by fermentation, including cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium including a source of sucrose, and recovering the 1,3-propanediol being produced.

Method for the preparation of 1,3-propanediol from sucrose

The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.

Growing community of inventors

Gerzat, France

Cédric Boisart