Other

Esperion Therapeutics, Inc.

Pharmacia & Upjohn Aktiebolag

Farmhispania S.a.

Lbp Istituto Faraceutico S.p.a.

Cesare Sirtori

Carlo Scolastico

Mats Lake

Erik Holmgren

Peter Lind

David Kritchevsky

Joanna Chmielewska

Guido Franceschini

Lars B Abrahmsen

Bj&ouml;rn M Nilsson

Bjorn Nilsson

Edoardo Butelman

Piero Gomarasca

Lars Abrahms&eacute;n

Substantially pure dimers of Apolipoprotein AI-Milano (APO-AI-M/APO AI-M) were isolated from plasma and characterized. Apolipoprotein AI-M dimer can also be produced in a recombinant system. Pharmaceutical compositions comprising the ApoAI-AI-M/ApoAI-M are described. Patients with atherosclerosis or cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used to prevent thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

Dimer of molecular variant of apolipoprotein and processes for the production thereof

Dimer of molecular variant of apolipoprotein and processes for the

Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose, galactose or mannose;

Synthetic amphiphilic glycoconjugates for neurological use

Pyrimidine and s-triazine derivatives of formula (I) ##STR1## in which X=CH or N; Y=for example halogen, alkoxy; W=for example --S--CH.sub.2 --COOH, --O--CH.sub.2 --COO alkyl, --NH--CH.sub.2 --CONHCH.sub.2 CH.sub.2 OH; Z=for example 2,3-xylidino, and methods for the preparation thereof are described. The compounds show high antilipemic activity.

Pyrimidine and s-triazine derivatives with antilipidemic activity

Novel compounds which are 7-acylderivatives of ursodeoxycholic acid are described of formula ##STR1## in which R-CO is the residue from a linear, saturated or unsaturated, carboxylic acid of 2-18 carbon atoms or the residue from a cycloalkanecarboxylic acid of 3-7 carbon atoms in the cycloalkane ring. The novel compounds are useful in the therapy of biliary calculosis, biliary diskinesia and hypertriglyceridemia.

Novel derivatives of ursodeoxycholic acid

Novel compounds are described, which are 7-acyl-chenodeoxycholic acid of formula (I) ##STR1## in which R-CO is the residue from a linear, saturated or unsaturated carboxylic acid of 3-18 carbon atoms or the residue from a cycloalkanecarboxylic acid of 3-7 carbon atoms in the cycloalkane ring. The compounds are prepared by selective hydrolysis of the 3,7-diacyl derivatives of chenodeoxycholic acid. The compounds are valuable against biliary calculosis, diskinesia and hypertriglyceridemia.

Derivatives of chenodeoxycholic acid

Growing community of inventors

Milan, Italy

Cesare Sirtori