Indena S.p.a.

Cesare Ponzone

Ezio Bombardelli

Paolo Morazzoni

Massimo Ronchi

Gabriele Fontana

Andrea Giori

Davide Berlanda

Pier P Puglisi

Antonella Riva

Mario De Rosa

Marco Bertani

Marcello Duranti

Fabio Donzelli

Andrea Gardi

Alessandro Consonni

Alessandra Morana

Antonella Di Lazzaro

Walter Acquati

Enzio Bombardelli

Extract obtainable by extraction fromsp. with mixtures of ethanol and water, characterised by an &#x3b1;-amylase inhibitor content in between 1,000 and 1,600 USP/mg (HPLC titre between 6 and 14% w/w) and a phytohaemagglutinin content in between 8,000 and 30,000 HAU/g, and a process for its preparation.

Phaseolus vulgaris extracts, their use and formulations containing them

A truncated form of &#x3b1;' chain (e&#x3b1;&#x2032;), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha&#x2032; subunit. The e&#x3b1;&#x2032; polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.

Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in HEP G2 cell cholesterol homeostasis

The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.

Biotransformation of colchicinoid compounds

The present invention relates to aextract with a high content of caffeoylquinic acids, and a composition containing saidextract with aextract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated inoil, fish oil, or oils rich in unsaturated &#x3c9;-3 fatty acids.

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The present invention relates to aextract with a high content of caffeoylquinic acids, and a composition containing saidextract with aextract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitizing the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated inoil, fish oil, or oils rich in unsaturated &#x3c9;-3 fatty acids.

This invention relates to the combination of &#x3b1;-amylase inhibitors prepared fromwith &#x3b1;-glucosidase inhibitors obtained fromand other species. The &#x3b1;-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with &#x3b1;-glucosidase inhibitors, such as extracts ofor the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.

Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity

A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis ofsteroid glycosides (ruscosaponins) by means of crude hydrolases from

Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic hydrolysis

A process for the preparation of desglucodesrhamnoruscin which comprises the hydrolysis of steroid glycosides (ruscosaponins) through fermentation of a substrate containing said glycosides by means of fungi of the species.

Process for the preparation of derivatives of ruscus aculeatus steroid glycosides

The present invention relates to the microbial biotransformation of colchiconic compounds into derivative compounds, which are glycosylated exclusively at the C-3 position of the six-member ring. The process of the present invention provides the 3-O-glycosyl derivatives in high yields and purity.

Process for the biotransformation of colchicone compounds into the correspondence 3-glycosyl derivatives

Process for the biotransformation of colchicinoid compounds into the

Hydroxyproline-rich proteins and pharmaceutical and cosmetic

Topical cosmetic and pharmaceutical compositions are provided for the external protection of human or animal tissues from contact with heavy metals, said compositions comprising a metal sequestering component capable of binding metal ions and a physiologically inert carrier suitable for topical administration. The said metal sequestering component comprises one or more metal binding peptide having a high proportion of cysteine residues, for example a metallothionein.

Topical cosmetic and/or pharmaceutical compositions

Topical cosmetic and pharmaceutical compositions are provided for the external protection of human or animal tissues from contact with heavy metals, and the composition includes a metal sequestering component capable of binding metal ions and a physiologically inert carrier suitable for topical administration. The metal sequestering component one or more metal binding peptide having a high proportion of cysteine residues, for example a metallothionein.

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Milan, Italy

Cesare Ponzone