Zambon Group

Simes Societa Italiana Medicinali E Sintetici

Simes

Pierrel Spa

Siphar S.a.

Simes Societa Italiana Medicinali & Sintetici Spa

Simes Societa Italiana Medicinali E. Sintetici S.a.

Simes Societa Italian Medicinali E Sintetici S.p.a.

Simes, Societa Italiana Medicinalle Sintetici

Cesare Casagrande

Francesco Santangelo

Giorgio Ferrari

Giorgio Bertolini

Stefania Montanari

Gabriele Pietro Norcini

Claudio Semeraro

Massimo Nicola

Vittorio Vecchietti

Francesco Marchini

Luciano Licciardello

Franco De Marchi

Paolo Ghirardi

Silvia Z Tricerri

Franco Pellacini

Annibale Gazzaniga

Leon I Goldberg

Emilio Mussini

Girogio Bertolini

Luciano Soldati

Theophile Godfraind

Germano Marchetti

Luisa Calabi

Maria L Calabi

A pharmaceutical composition is described comprising ibopamine and an ACE-inhibitor. Such composition is useful in the treatment of cardiovascular diseases, more particularly of hypertension and heart insufficiency even when the latter is associated with or caused by hypertension.

Pharmaceutical composition useful for the treatment of cardiovascular

Pharmaceutical compositions for the treatment of cataract containing N-acetyl-L-cysteine derivatives of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) are described.

Pharmaceutical compositions containing N-acetyl-cysteine derivatives

Compounds of the formula ##STR1## (wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing them. The compounds of formula I are active on the cardiovascular system as antivasospastics, antiangina agents, antihypertensives and vasodilators.

Compounds active on the cardiovascular system

Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described. The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of peripheral arteriopathies and in cerebrovascular insufficiency.

2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the

Diphosphates of catecholamines having formula (I) wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X have the meanings reported in the description, are useful in the therapy of cardiovascular and renal diseases. ##STR1##

Diphosphates of catecholamines and pharmaceutical compositions

Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R.sub.1 and R.sub.2 have the meanings mentioned in the description are described.

Steroid compounds active on the cardiovascular system

A process is disclosed for the preparation of 2-amino-5,6-dimethoxy-tetralin, which is a useful intermediate for the preparation of pharmacologically active chemical compounds.

Process for the preparation of 2-amino-5,6-dimethoxy-tetralin

The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, as described. The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.

Compounds active as inhibitors of the cholesterol biosynthesis

Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described. The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.

Phenoxyethyl amine compounds active on the cardiovascular system

The compound of the formula ##STR1## (wherein R, R.sub.1 and R.sub.2 have the meanings given in the description), salts thereof with pharmaceutically acceptable organic or inorganic acids, process and intermediates for the preparation thereof and a pharmaceutical composition containing said compound are described. The compounds of formula I and the salts thereof are useful in the treatment of heart and renal diseases.

Catecholamine esters

A process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives by treatment of a mixture of both 3-O-phosphate and 4-O-phosphate isomers with a strong mineral acid and optional esterification of the so obtained phosphoric ester of dopamine or dopamine derivatives is described.

Process for the preparation of 4-O-phosphates of dopamine and dopamine

Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and Z have the meanings reported in the specification, and intermediates for their preparation are described. The compounds of formula I have antiatherosclerotic activity as inhibitors of the enzyme HMG-CoA reductase and they are useful in the pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

1,2,3-triazole compounds active as inhibitors of the enzyme HMG-CoA

A monophosphorylated L-dopa ester of formula ##STR1## (wherein the asterisk, R, R.sub.1, R.sub.2 and R.sub.3 have the meanings shown in the description),

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Arese, Italy

Cesare Casagrande