University of South Florida

Augusta University Research Institute, Inc.

Sanbio, Inc.

Abt Holding Company

Athersys, Inc.

Medical College of Georgia Research Institute, Inc.

Cesar V Borlongan

Casey Christopher Case

Robert J Deans

Robert W Mays

David C Hess

James E Carroll

Casey C Case

The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.

MAPC treatment of brain injuries and diseases

Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain. The transplanted cells form a pathway along which endogenous neurogenic cells proliferate and migrate from the subventricular zone to the site of injury.

Methods and compositions for modulation of migration of neurogenic cells

Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells

Growing community of inventors

Tampa, FL, United States of America

Cesar V Borlongan