University of Arkansas

The United States Government As Represented by the Department of Veterans Affairs

Bioventures, LLC

Universidad Tecnica Particular De Loja

Cornell University

Other

Tocol Pharmaceuticals, LLC

New York Botanical Garden

Cesar M Compadre

Philip J Breen

E Kim Fifer

Danny L Lattin

Hamid Salari

Yanbin Li

Michael F Slavik

Timothy J O'Brien

Martin Hauer-Jensen

Darin E Jones

Amy L Waldroup

Richard Drake

Barry Hurlburt

Tammy M Rechtin

Nukhet Aykin-Burns

Omar Malagon

Thomas F Berg

Trenton Hinds

Peter Anthony Crooks

Mark S Smeltzer

Shraddha Thakkar

Monica L Guzman

E Nathalie Pineda

Cassandra L Quave

Howard Hendrickson

Raul G Enriquez

Sujay Kharade

Yadira Ordonez

Paola E Ordonez

Edgar Ojeda

Guangrong Zheng

Phillip V Engler

Mariano Martinez

Michael J Balick

Mike Slavik

Flavio G Gaudio

Giovanni Vidari

Omar Malagon AVILÉS

Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.

Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation

The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.

Dehydroleucodine derivatives and uses thereof

The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

Hetero-substituted cyclic lactone analogues and uses thereof

Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise &#x3b3;-tocotrienol (GT3) and &#x3b4;-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.

Preparation and use of a composition for prevention and mitigation of the effects of radiation

The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.

Anti-biofilm compositions and methods for using

Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogs are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.

Methods for making tocoflexols and analogues thereof

A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

Concentrated, non-foaming solution of quaternary ammonium compounds and methods of use

A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.

Mutated herpes simplex virus type 1 thymidine kinases and uses thereof

Concentrated, non-foaming solution of quarternary ammonium compounds and methods of use

A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin-producing Escherichia, and pathogenic toxin-producing Escherichia, such as 0157:H7; fungi, such as Aspergillus flavus and Penicillium chrysogenum; and parasites, such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit. One of the treatment methods is spraying quaternary ammonium compounds on the food products to prevent broad spectrum foodborne microbial contamination. New formulations of quaternary ammonium compounds combined with glycerin and/or ethyl alcohol provides a concentrated formulation for industrial use and a diluted formulation for use in spraying methods.

Method for the broad spectrum prevention and removal of microbial

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Little Rock, AR, United States of America

Cesar M Compadre