University of Southern California

Pulse Biosciences, Inc.

Puise Biosciences, Inc.

Cesar Escobar Blanco

David Alvin Tyvoll

Bharat Kumar Menon

Nan Chen

Heather Michelle Grandin

Elena Tovkan Forster

Stefani Reiko Takahashi

Jean-Michel I Maarek

Daniel P Holschneider

Frances Richmond

Jonathan Gregory Lasch

Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).

Metal oxide nanostructured surfaces

This disclosure relates to an in vivo treatment of tissue, for example, a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.

Marking tissue surfaces for treatment of lesions by electrical nanopulses

This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.

This disclosure relates generally to adhesive articles and particularly to adhesive articles comprising a reversible adhesive layer and a non-reversible adhesive layer. The adhesive article may further comprise a backing material. The adhesive article may further comprise a dressing material. Such adhesive articles may be particularly suitable for treatment of damaged sensitive tissue, for example wounds formed on a fragile skin.

Adhesive articles

A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.

Growing community of inventors

Los Angeles, CA, United States of America

Cesar Escobar Blanco