Université De Franche Comte

Centre Hospitalier Universitaire De Besançon

Celine Viennet-Steiner

Lionel Pazart

Philippe Humbert

Sophie Robin

Helene Tauzin

Delphine Binda

Gwenael Rolin

The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular matrix; at least one pluridimensional medium is soaked with said mixture; from the components of the mixture, a lattice comprising at least one element of an extracellular matrix is produced, at least at the medium; at least part of the components of said mixture is attached to the structure of the medium; the shrinking of at least the lattice is prevented and at least said lattice is tensioned on said medium; fibroblasts are integrated into the lattice and at least one cell culture of said fibroblasts is carried out, at least in the lattice. The invention also relates to a method for producing a skin equivalent that comprises at least one dermal equivalent formed by an unshrunken tissue equivalent and at least one epidermal equivalent.

Unshrunken tissue equivalent and methods for producing such an unshrunken tissue equivalent

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Ornans, France

Celine Viennet-Steiner