Ucb Pharma, S.a.

Ucb Pharma Gmbh

Ucb S.a.

Celal Ates

Arnaud Schule

Emile Cavoy

John Surtees

Nicolas Edmond Carly

Magali Palacio

David Vasselin

Anne-Catherine Burteau

Violeta Marmon

Yannick Quesnel

Francoise Lurquin

Jean-Pierre Delatinne

Paul Deutsch

Ganesh Phadtare

Swapnil Yerande

Maria Luisa Escudero Hernandez

The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R, Rand Rare as defined for compound of formula (I). 

Process for the preparation of nitrogen substituted aminotetralins derivatives

The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives. 

2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses

The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A). 

The present invention relates to 3-carboxy-2-oxo-1-pyrrolidine derivatives of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof, and processes using them. 

3-carboxy-2-oxo-1-pyrrolidine derivatives and their uses

The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine. 

Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes. 

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191&#x2013;C?4#191 alkyl, C?2#191&#x2013;C?4#191 alkenyl or C?2#191&#x2013;C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes 

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Louvain-la-Neuve, Belgium

Celal Ates