10X Genomics, Inc.

Cedric Uytingco

Yifeng Yin

Jennifer Chew

Marlon Stoeckius

Rajiv Bharadwaj

Augusto Manuel Tentori

Layla Katiraee

Christina Galonska

David Sukovich

James Michael Chell

Albert Dale Kim

Joseph Francis Shuga

Kristen Pham

Aleksandra Jurek

Octavian Marian Bloju

Dulce Ovando Morales

Andrej Hartnett

Patrick Roelli

Ryo Hatori

Rapolas Spalinskas

Mesruh Turkekul

Anna-Maria Katsori

Andrew D Price

Zachary Bent

Joakim Lundeberg

Hanyoup Kim

Bill Kengli Lin

Steven W Short

Eswar Prasad Ramachandran Iyer

Felice Alessio Bava

David Maurice Cox

Siyuan Xing

Linda Kvastad

Jill Herschleb

Alexander Hermes

Denise Cheung

Naishitha Anaparthy

Erica Graziosa

Meghan L F Frey

Fernandino Valdecanas

A method for aligning a sample to an array is provided. An image of sample image of a sample can be received by a data processor. The sample image having a first resolution. An array image including an overlay of an array with the sample and an array fiducial can be received by the data processor. The array image having a second resolution lower than the first resolution of the sample image. The sample image can be registered to the array image by aligning the sample image and the array image. An aligned image can be generated based on the registering. The aligned image can include an overlay of the sample image with the array. The aligned image can be provided by the data processor. A method for detecting fiducials associated with an array is provided. Systems and non-transitory computer readable mediums performing the method are also provided.

Sample handling apparatus and image registration methods

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

Imaging system hardware

Provided are methods of capturing an analyte from a biological sample using a hydrogel that includes capture probes to capture the analyte, identifying a region of interest of the biological sample, and isolating the region of interest from the biological sample by removing a portion of the hydrogel that corresponds to the region of interest. Compositions and kits for performing the methods are also provided.

Spatial analysis utilizing degradable hydrogels

Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

Multiplex capture of gene and protein expression from a biological sample

Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.

Simultaneous spatio-temporal measurement of gene expression and cellular activity

Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.

Spatially-tagged analyte capture agents for analyte multiplexing

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Pleasanton, CA, United States of America

Cedric Uytingco