Recursion Pharmaceuticals, Inc.

Cedric St-Jean-Leblanc

Mason L Victors

Blake C Borgeson

Systems and methods for determining whether a set of test perturbations discriminates over a null distribution for an on target effect against a first component of an entity are disclosed. The perturbations are perturbations of the first component and the entity comprises a plurality of components. For each perturbation in the set, a corresponding vector comprising a plurality of elements, is obtained. Each element comprises a distribution metric of measurements of a feature across instances of the entity upon exposure to the respective perturbation or (ii) a distribution metric of a respective dimension reduction component computed using the measurement of the plurality of features across instances of the entity upon the perturbation exposure. A composite metric is computed, using the vectors, and compared to a null distribution. When the composite metric is differentiated from the null distribution, the set of perturbations is deemed to discriminate the on target effect against the first component over the null distribution.

Systems and methods for discriminating effects on targets

A method for determining whether a set of perturbations discriminates over a null distribution for an on target effect against a first component of an entity is provided. The set of perturbations comprises perturbations of the first component and the entity comprises components including the first component. There is obtained, for each respective perturbation, a corresponding vector, thereby obtaining a plurality of vectors. Each such vector comprises a plurality of elements. Each element comprises (i) a distribution metric of a different feature, in a plurality of features, across a plurality of instances of the entity upon exposure of the plurality of instances of the entity to the respective perturbation or (ii) a distribution metric of a respective dimension reduction component computed using the plurality of features for a plurality of instances of the entity upon exposure of the plurality of instances of the entity to the respective perturbation.

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Montreal, Canada

Cedric St-Jean-Leblanc