Forschungsverbund Berlin E.v.

Universität Zu Koln

Klockner Pentaplast Gmbh

Cedric Reuter

Ronald Kühne

Hartmut Oschkinat

Hans-Günther Schmalz

Christian Kohlert

Matthias Müller

Robert Opitz

Matthias Barone

Arne Soicke

Peter Huy

Adrian Fasel

Sascha Jürgens

Evgeny Belukhichev

The present invention relates to chemical compounds that can in particular be used as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of said compounds as pharmaceutical agents and to the use of the pharmaceutical agents to treat tumor diseases. The chemical compounds of the present invention can significantly inhibit the chemotaxis and motility of invasive tumor cells and can therefore be used in the treatment and/or prevention of tumor metastases.

Inhibitors for inhibiting tumor metastasis

The invention relates to compounds that can be used, in particular, as structural mimetics of proline-rich peptides and are correspondingly able to bond with proline-rich-motif binding domains (PRM domains) of proteins. The invention further relates to the use of these compounds as pharmaceutically active agents, as well as the use of the pharmaceutically active agents for the treatment of bacterial, neurodegenerative and tumor diseases.

Structural mimetics of proline-rich peptides and use thereof

Growing community of inventors

Kö'ln, Germany

Cedric Reuter