Novasep Process Solutions

Novasep Process

Cédric Prieur

Eric Valéry

Eric Valery

Stéphane Oliveira

Nicolas Pautal

The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises measuring the purity and/or yield of a collected fraction, comprising: the determination, in a node of the system, of the histories of at least two variables that are representative of the concentration of at least two species contained in the mixture to be separated using at least one fast online detector; the determination of the concentration of at least two species of the mixture to be separated in the collected fraction based on these histories; and the determination of the purity and/or yield of the collected fraction based on these concentrations.

Regulated method for separating a mixture

The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.

The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically:

Method for chromatographic purification of viscous loads

The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; the volume of the mobile phase injected per cycle being maintained higher than, or equal to, a minimum threshold and/or lower than, or equal to, a maximum threshold. The invention also relates to a computer program for carrying out the steps of such a method, to a storage medium on which such a program is recorded, and to a system comprising a processor coupled to a memory on which such a program is recorded.

The invention relates to a method for purifying a solution, the method comprising the following successive steps: &#x2014;bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 &#x3bc;m; &#x2014;separating the solution into a purified solution and a loaded resin; &#x2014;regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.

Purification method using a low granulometry resin

The invention relates to a fluid distributor () for a column () comprising at least one cell () containing a bed of particles (), the fluid distributor () comprising: &#x2014;a floor () comprising at least one injection point () providing a fluidic connection on either side thereof; &#x2014;a layer of a resistive medium () fixed on one face of the floor (), the resistive medium being permeable to the fluid; &#x2014;a spacing device () inserted between the floor () and the layer of resistive medium () and maintaining a space for the circulation of the fluid between the floor () and the layer of resistive medium (). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

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Genas, France

Cédric Prieur