Centre National De La Recherche Scientifique

Universitè De Montpellier

Université Pierre Et Marie Curie

Universite Montpellier 2

Cedric Mongellaz

David Klatzmann

Marc Sitbon

Marcos Steinberg

Jean-Luc Battini

Naomi Taylor

Gilles Marodon

Oumeya Adjali

Chantal Jacquet

Naomi Sitbon

A method for the identification and quantification of the expression of membrane receptors present on the surface of target cells using at least two soluble receptor binding ligands derived from the soluble part of the glycoprotein of an enveloped virus that interacts with a cellular cognate receptor, the receptor binding ligand containing a part or the totality of one of the receptor binding domains (RBD) of the glycoprotein, and the soluble receptor binding ligand being liable to interact with the at least one membrane receptor of a target cell, for the identification and quantification of the expression of membrane receptors present on the surface of target cells, the identification and quantification taking place at a given time or during a given time interval, and allowing the determination of a physiological state of the target cell.

Receptor binding ligands, their use in the detection of cells with biological interest

The invention relates to the use of viral vectors able to stably integrate into the genome of thymic stromal cells, or of intrathymic lymphocytes or lymphocytes precursors, for the manufacture of a medicine intended for intrathymic administration in the frame of the prevention or treatment of genetic immunodeficiencies, acquired immunodeficiencies, or for the induction of immune tolerance of the organism to self or non-self gene products, cells or tissues, or for the prevention or treatment of autoimmune diseases.

Treating immunodeficiencies by intrathymic injection of nucleotide sequences

Growing community of inventors

Montpellier, France

Cedric Mongellaz