Other

Ampsource Biopharma Shanghai Inc.

Livzon Mabpharm Inc.

Cecily Rou-Yun Sun

Bill Nai-Chau Sun

Qiang Li

Lee-Hwei King Sun

Si Ruo Chen

Yuncheng Zheng

Zhenxiang Hu

Yongjuan Gao

Zhu Wang

Baoguo Zhu

Yucai Peng

Ruey Shyan Liou

Jingwei Zhang

Ruey-shyan Liou

Desheng Tao

The invention provides an antibody and/or an antigen binding fragment that binds to NGF, and the amino acid sequences of the heavy chain and light chain variable regions of the antibody. The NGF antibody and/or its antigen binding fragment provided by the invention has high affinity for NGF and can effectively block the binding between NGF receptor and NGF. This antibody and/or its antigen binding fragment can inhibit the binding activity of NGF and its receptor in vitro, and is suitable for the treatment of pain diseases which are related to the haughty expression or increased expression of NGF.

Anti-human NGF antibodies and methods using same

The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.

Humanized anti-TNF&#x3b1; antibodies

Fc fusion proteins of human growth hormone with good biological activities relative to rhGH on a molar basis are disclosed. The hGH-L-vFc fusion protein comprises hGH, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hGH-L-vFc fusion proteins exhibit extended or prolonged serum half-life and/or good biological activities relative to that of rhGH on a molar basis, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.

Fc fusion proteins of human growth hormone

Growing community of inventors

Shanghai, China

Cecily Rou-Yun Sun