Baxter International Inc.

Cecilia S Ku

Richard J Johnson

Julian P Breillatt, Jr

Julian Breillatt

A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.

Analogs of hirudin

Thromboresistant materials are disclosed comprising hirudin or hirudin derivatives covalently linked to support materials such that the resultant composition has substantially the same biological activity as hirudin. Methods for making such compositions are also disclosed.

Growing community of inventors

Lake Forest, IL, United States of America

Cecilia S Ku