Nsgene A/s

Stemcells California, Inc.

Nsgene Sa

Cecilia Eriksson

Lars U Wahlberg

Kenneth Campbell

Klas Wictorin

Charlotta Skogh

Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.

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Cultures of GFAP nestin cells that differentiate to neurons

Cultures of GFAP+ nestin+ cells that differentiate to neurons

Growing community of inventors

Falsterbo, Sweden

Cecilia Eriksson