Children's Medical Center Corporation

Cecilia A Fernandez

Marsha A Moses

Inmin Wu

The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1, or a fragment thereof, which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the fragment has at least 50% inhibition of bFGF-stimulated EC proliferation at 5 &#x3bc;g/ml-20 &#x3bc;g/ml, more preferably 75% inhibition, most preferably 95% inhibition.

Antiangiogenic peptides

The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 or a portion thereof which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the portion has at least 50% inhibition of bFGF-stimulated EC proliferation at 5 Tg/ml, more preferably 75% inhibition, most preferably 95% inhibition.

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Jamaica Plain, MA, United States of America

Cecilia A Fernandez