Spi Pharma, Inc.

Other

Corn Products International, Inc.

Goll, Diane

Propst, Cecil W.

Cecil W Propst

Marc W Meadows

Michael S Todd

John Tillotson

Diane Goll

Ronald C Deis

The present invention relates to microspheres comprising a core material, wherein the microsphere is perfectly spherical and has a moisture content less than 1%, and the method of manufacturing the same. The present invention is useful in the manufacture of sustained and modified release active pharmaceutical ingredient (API) microspheres, as a free flowing excipient for mini-tablets and in the manufacture of API dispersions.

Crystalline microspheres and the process of manufacturing the same

A composition comprising a core material, having a taste value and a polymeric coating. The polymeric coating substantially surrounds the core material and comprises a cationic polymer and optionally an anionic polymer. The polymeric coating has a uniform thickness ranging from 2 &#x3bc;m to 20 &#x3bc;m. The composition provides release of a portion of the core material which is taste masked over a time period ranging from 0.5 minute to 2 minutes in the oral cavity and provides a modified-release of the remaining core material in a gastrointestinal tract.

Microencapsulation process and product

The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.

Highly compactable and durable direct compression excipients and excipient systems

Microspheres comprising a core material, wherein the microspheres have a circularity greater than 0.95 and an aspect ratio greater than 0.95, and methods of manufacturing the same. The microspheres may be useful in the manufacture of sustained and modified release active pharmaceutical ingredient (API) microspheres, as a free flowing excipient for mini-tablets and in the manufacture of API dispersions.

The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.

The present invention includes methods for preparing polyol products including a method of making a free-flowing granular product comprising: a) charging hydrogenated starch hydrolysate to an agglomerator; b) adding polyol syrup to the maximum loading capacity of the hydrogenated starch hydrolysate; and c) adding polyol crystals in an amount sufficient to dry the product. The present invention also includes compositions comprising polyol products for use in pharmaceuticals, nutraceuticals, foods, such as frozen dairy and bakery items, and confections.

Growing community of inventors

Norton Shores, MI, United States of America

Cecil W Propst