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Cecil Pace-Asciak

Jean-Philippe Meyer

Alexandra SantAna Sorensen

Peter Denim

The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration. 

Hepodxilin analog enantiomers

Methods and compositions employing as active ingredient hepoxilins and hepoxilin analog useful for inhibiting thromboxane formation and antagonizing thromboxane activity. Methods and compositions employing these compounds provide treatment for a number of disease conditions.

Inhibitors of thromboxane formation and action

Methods and pharmaceutical compositions comprise at least one hepoxilin analog of the formula (I) wherein X and Rare as defined herein. The methods are directed to treatment of a cancer and for promotion of a apoptosis in a cancer cell.

Compositions comprising hepoxilin analogs and their use in the treatment of cancer

The present invention relates to the use of native hepoxilins and of hepoxilin analogs for the regulation of insulin secretion and to the use of hepoxilin analogs as anti-inflammatory, anti-diabetic and anti-thrombotic compounds.

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Toronto, Canada

Cecil Pace-Asciak