University of Missouri

Cathy Sue Cutler

Hendrik Petrus Engelbrecht

Kattesh V Katti

Kavita K Katti

Silvia S Jurisson

Stacy Lynn Wilder

Anthony J DeGraffenreid

Leonard Manson

Delbert E Day

Raghuraman Kannan

Gary J Ehrhardt

Henry W White

Satish Kumar Nune

Anandhi Upendran

Ajit Zambre

Nripen Chanda

Charles W Caldwell, Jr

Ravi Shukla

Kattesh K Katti

Menka Khoobchandani

Donald E Wycoff

Kativa K Katti

Leonard Iii Manson

Hendrik P Engelbrecht

A method for forming encapsulated gold nanoparticles mixes mangiferin into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts is permitted, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible gold nanoparticles coated with mangiferin. The gold salts can consist of AuCl4, or can consist of radioactive gold salts. A cancer therapy method injects a solution of mangiferin encapsulated gold nanoparticles directly into a solid tumor. A solution consisting of an aqueous or alcoholic medium and mangiferin encapsulated gold nanoparticles is provided. The mangiferin encapsulated gold nanoparticles can have core sizes of &#x2dc;5-20 nm and total sizes of &#x2dc;20-120 nm.

Mangiferin encapsulated gold nanoparticles, fabrication methods and cancer therapeutic methods

A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsOto separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.

Method for separation of chemically pure Os from metal mixtures

The present invention provides radioactive arsenic complexes useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.

Arsenic complexes for potential diagnostic applications

The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.

Radioisotope trithiol complexes

The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavonoids-rich plant material that can be obtained from green tea. The EGCg is an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-/EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles.

EGCG stabilized gold nanoparticles and method for making same

The present invention provides a simple and inexpensive method for removing metal and other impurities in a radioisotope solution. The invention further includes the development of a new parent/daughter generator system for collecting the daughter isotope in a concentrated solution.

Method and system for purifying charged radioisotopes

An example embodiment of a method for making gold nanoparticles includes steps of reacting a gold salt with a phosphino amino acid. Example phosphino amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphino group. In an example method of the invention, the gold nanoparticles may be produced in timer periods of less than about 3 minutes, and at temperatures of less than about 30&#xb0; C. Other methods of the invention are directed to methods for stabilizing gold nanoparticles, and to methods for making gold nanochains.

Methods and articles for gold nanoparticle production

Growing community of inventors

Columbia, MO, United States of America

Cathy Sue Cutler