Novartis Ag

Cathy Ritchie

Nikolaus Johannes Stiefl

Duncan Shaw

Ian Bruce

Benoit Hornsperger

Catherine Leblanc

Bernard Cuenoud

Emma Budd

Catherine LeBlanc

Sven Weiler

Darren Mark Le Grand

Judy Fox Hayler

Thomas Hugo Keller

Dimitrios Lizos

Vikki Furminger

Sarah Lewis

Nicola Press

Gaynor Elizabeth Pilgrim

Barbara Valade

Compounds of formula (I): in free or salt or solvate form, where X, R, R, Rand Rhave the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. 

Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors

Compounds of formula I in free or salt form, wherein R, R, Rand Rhave the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Inhibitors of phosphatidylinositol 3-kinase

Compounds of formula I: in free or salt or solvate form, where R, R, Rand Rhave the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis. 

Organic compounds

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Cathy Ritchie