The General Hospital Corporation

Fujifilm Corporation

Children's Medical Center Corporation

Massachusetts Eye and Ear Infirmary

Cathryn Sundback

Koju Ito

Shinji Mima

Chihaya Kakinuma

Theresa Anne Hadlock

Craig M Neville

Joseph P Vacanti

Masafumi Nishino

Erik Bassett

Mark Randolph

Theresa A Hadlock

Irina Pomerantseva

Daichi Hikimoto

Mack Cheney

Takafumi Suehiro

The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μm to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%.

Blood vessel model

A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance

The present invention provides for compositions and constructs for craniofacial reconstruction implants, and methods for making and using same. Specific embodiments provide for a biocompatible scaffold having an auricular shape and a permanent bendable framework within the scaffold, wherein the permanent bendable framework allows deformation and return to pre-deformation shape, and thus maintains the auricular shape of the scaffold.

Engineered craniofacial constructs with composite scaffold

A guidance channel or conduit for promoting nerve regeneration includes a body constructed of a biocompatible polymeric material and having a first end for connection to a proximal stump of a severed nerve and a second end for connection to a distal stump of the severed nerve. The body includes a plurality of internal lumens extending between the first and second end to facilitate rejoining of the proximal and distal stumps of the severed nerve by providing increased surface area for Schwann cell adherence. A method for promoting nerve regeneration using a multi-lumen nerve guidance channel is also disclosed.

Multi-lumen polymeric guidance channel and method of manufacturing a polymeric prosthesis

Multi-lumen polymeric guidance channel, method for promoting nerve

Growing community of inventors

Harvard, MA, United States of America

Cathryn Sundback