The University of Chicago

Cathryn R Nagler

Jeffrey Alan Hubbell

Ruyi Wang

D Scott Wilson

Catherine Plunkett

Gabriel Nunez

Yun-Gi Kim

Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease

Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.

Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA)

Growing community of inventors

Chicago, IL, United States of America

Cathryn R Nagler